Despite recent declines, substantial disparities persist in teen birth rates, and teen pregnancy and childbearing continue to carry significant social and economic costs. The U.S. teen pregnancy, birth, sexually transmitted disease (STD), and abortion rates are substantially higher than those of other western industrialized nations. Over the past two years, multiple Federal offices have coordinated efforts to address the critical issue of teen pregnancy prevention. The Office of Adolescent Health (OAH), Administration for Children Youth and Families/Family Youth Services Bureau (ACYF), and the Centers for Disease Control and Prevention/Division of Reproductive Health (CDC) each administer teen pregnancy prevention grant programs to target the issue from a different approach. The TPP programs administered by these three agencies are an example of how the Administration is seeking to ensure that the best evidence is brought to bear in public programs – and that we continue to build our knowledge bank about what works, and what doesn’t, so that we improve the effectiveness of programs and make the best use of scarce resources. Through this panel presentation, these three offices will share lessons learned and successful strategies regarding program rollout, implementation, and collaboration efforts. Participants will have the opportunity to engage in a Q&A session with the panel members. OAH provides funds to a diverse group of grantees to replicate evidence-based teen pregnancy prevention programs with fidelity and to test innovative approaches to preventing teen pregnancy. OAH grantees are conducting rigorous grantee-level evaluations of their efforts to replicate evidence-based programs and to test new approaches to teen pregnancy prevention that will continue to add to the evidence-base and expand knowledge on what works. ACYF provides funds to State agencies, Tribes, and other organizations to educate young people on both abstinence and contraception and to support research and demonstration projects that implement innovative strategies. CDC, in collaboration with OAH, provides funds to implement and evaluate a community-wide approach to preventing teen pregnancy that includes community mobilization and stakeholder education, implementation of evidence-based programs, access to youth-friendly clinical services, and working with diverse communities. OAH will share lessons learned related to program development and implementation of evidence-based programs, innovative demonstration programs, and collaboration efforts. OAH has identified numerous lessons and successes during both the program’s piloting and full implementation phases. ACYF will share successes and challenges from the rollout of large-scale programming with States and Tribes. ACYF will share findings from a design study conducted to help them in this process. CDC will provide examples of tailored grantee efforts to develop, implement and evaluate innovative, multi-component, community-wide initiatives in reducing rates of teen pregnancy and births in communities with the highest rates, with a focus on African American and Latino/Hispanic youth aged 15–19. Community-wide approaches include broad-based strategies that reach a majority of youth in the community (e.g., through communication strategies and media campaigns); and strategies reaching youth most in need of prevention programming. Audience members will be able to translate these lessons and successes into their own work with evidence-based and innovative program services.